Quantitative Method for the Determination of Posaconazole in Mouse Tissues using Liquid Chromatography-Mass Spectrometry
نویسندگان
چکیده
Posaconazole is a highly lipophilic drug. It is one of the more recent triazole antifungals critical in the treatment of invasive mycoses [1]. It disturbs fungi growth by inhibiting cytochrome P450 lanosterol 14α-demethylase (CYP51A1) that leads to blockage of ergosterol synthesis in the fungal cell membranes. The end result of this reaction is the increase of fungi cell membrane permeability and cessation of cell growth and replication [2,3]. Posaconazole is active against several organisms including Candida spp, zygomycota and Aspergillus spp [4,5].
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تاریخ انتشار 2014